Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in
various species. In vertebrates, melatonin is produced predominantly by the pineal gland …

Sexual dysfunction is a common symptom of depression. Although decreased libido is most
often reported, difficulties with arousal, resulting in vaginal dryness in women and erectile …

Agomelatine is a novel antidepressant acting as a melatonergic receptor agonist and
serotonergic (5-HT 2C) receptor antagonist. In adult rats, chronic agomelatine treatment …

Depression is one of the leading causes of morbidity worldwide and represents a huge
burden to society. As with many other psychiatric disorders, a genetic basis for depression …

There are many potentials for the development of more effective, better tolerated, and more
rapidly acting antidepressants. As there is large prevalence of circadian dysfunction in …

Background: The World Health Organization (WHO) report has predicted that major
depression will become a key cause of illness-induced disability by the year 2020, second …

Agomelatine, a novel antidepressant with established clinical efficacy, acts as a melatonin
receptor agonist and 5-HT2C receptor antagonist. As stress is a significant risk factor in the …

Despite adequate antidepressant monotherapy, the majority of depressed patients do not
achieve remission. Even optimal and aggressive therapy leads to a substantial number of …

The link between co-morbid insomnia and depression has been demonstrated in numerous
groups. Insomnia has been associated with:(1) an increased risk of developing subsequent …

Some core symptoms of major depression show a circathan rhythm in their clinical
manifestations or are closely linked to the circadian system functioning, such as sleep-wake …