Microfabricated systems provide an excellent platform for the culture of cells, and are an
extremely useful tool for the investigation of cellular responses to various stimuli …

A microfabrication approach was utilized to create topographic analogs of intestinal crypts
on a polymer substrate. It was hypothesized that biomimetic crypt-like micro-architecture …

Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the
design of systems for regenerative medicine and tissue engineering. These rapidly growing …

Tissue engineering is becoming increasingly ambitious in its efforts to create functional
human tissues, and to provide stem cell scientists with culture systems of high biological …

One of the greatest impacts on in vitro cell biology was the introduction of three-dimensional
(3D) culture systems more than six decades ago and this era may be called the dawn of 3D …

In the course of the present work new strategies for the structuring of surfaces utilizing
different “top-down” and “bottom-up” methods were developed. The central “bottom-up” …

A combination of nanotopography and controlled release could be a potential treatment for
damages to the central and peripheral nervous system. Synergistic effects of both physical …

Etching of hydrogen-terminated Si (100) in deoxygenated water produces surfaces with a
regular nanoscale topography. Surface infrared spectroscopy provides detailed information …

The evolution of glycosaminoglycans (GAGs) in eukaryotic species has been one of great
biological mysteries. This thesis investigates the composition, rate of degradation and …