The MHC class II association with MS is not as straightforward as previously thought. A
complete understanding of the epistatic interactions and epigenetic features of this region …

Background Both human leukocyte antigen (HLA)-DRB1* 15 and Epstein-Barr virus
infection presenting as infectious mononucleosis (IM) are recognized as risk factors for …

Background In those with multiple sclerosis (MS), African American individuals have a more
severe disease course, an older age at onset, and more often have clinical manifestations …

Multiple sclerosis (MS), like many putative autoimmune diseases, has been known to be
associated with the human leukocyte antigen (HLA) class II region for more than 3 decades …

Abstract Carriage of HLA-DRB1⁎ 15 is the most important genetic risk factor in multiple
sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (OCB) constitute the …

Background: Multiple sclerosis (MS) displays a month-of-birth effect, with an excess of
individuals being born in the spring and a deficit in the winter. This effect was shown to be …

The ages of onset in multiple sclerosis cases span more than 7 decades. Data are
presented for affected relative pairs from a Canadian population base of 30,000 multiple …

Among all of the genetic factors associated with multiple sclerosis (MS) susceptibility, MHC
class II molecules have the strongest association. Although a direct role of DR alleles in MS …

Human leucocyte antigen (HLA)‐DRB1* 1501 and other class II alleles influence
susceptibility to multiple sclerosis (MS), but their contribution if any to the clinical course of …

Association of HLA class II with multiple sclerosis (MS) has been widely studied in both
Western and Oriental populations. However, such an association is not well documented in …