The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …

Loganin is an iridoid glycoside found in the Flos lonicerae, Fruit cornus, and Strychonos nux
vomica. We investigated the effect of loganin on learning and memory impairments induced …

Dementia is a chronic progressive mental disorder, which adversely affects memory,
thinking, comprehension, calculation and language. Some of the commonest forms of …

In view of the nonavailability of complete X-ray structure of carbamates cocrystallized with
AChE enzyme, the 3D-QSAR model development based on cocrystallized conformer …

Purpose. Alzheimers disease is characterized by a dysfunction of central cholinergic
systems and is treated by inhibitors of acetylcholinesterase (AChE). This study tests the …

Current treatments of Alzheimer's disease include the allosteric potentiation of nicotinic
acetylcholine receptor (nAChR) response. The location of the binding site for allosteric …

Amyloid-β-induced neuroinflammation plays a central role in the extensive loss of
cholinergic neurons and cognitive decline in Alzheimer's disease. The acetylcholinesterase …

An electrophoretically mediated microanalysis technique was developed for the rapid
screening of acetylcholinesterase inhibitors. Activity of four original compounds, N …

Abstract Distigmine bromide (3, 3'-[hexamethylenebis (methyliminocarbonyloxy)] bis (1-
methylpyridinium) dibromide), an acetylcholinesterase (AChE) inhibitor, produced a time …

A doença de Alzheimer (AD) é considerada a forma mais comum de demência na
população idosa. O cérebro de um doente de AD é caracterizado por uma deficiência na …