Context: Hyper-and hypoglycemia are associated with increased mortality of critically ill
patients, but whether this association is causal remains unclear. Early randomized …

The hypothesis proposed is that heart failure (HF) is associated with a reactive
hyperadrenergic state that increases circulating plasma free fatty acids (FFAs), which leads …

People with diabetes are more likely to be hospitalized and to have longer durations of
hospital stay than those without diabetes. A recent survey estimated that 22% of all hospital …

Purpose An optimal target for glucose control in ICU patients remains unclear. This
prospective randomized controlled trial compared the effects on ICU mortality of intensive …

In modern surgical practice it is advisable to manage patients within an enhanced recovery
protocol and thereby have them eating normal food within 1–3days. Consequently, there is …

Background Critically ill infants and children often develop hyperglycaemia, which is
associated with adverse outcome; however, whether lowering blood glucose concentrations …

Introduction Critically ill patients are characterized by increased loss of muscle mass,
partially attributed to sepsis and multiple organ failure, as well as immobilization. Recent …

The incidence and mortality of sepsis and the associated development of acute kidney injury
(AKI) remain high, despite intense research into potential treatments. Targeting the …

Hyperglycemia and insulin resistance often occur following injury and/or critical illness.
Whereas intensive insulin treatment reduces hyperglycemia, mortality and morbidity in …

Perioperative hyperglycemia in critically ill surgery patients increases the risk of
postoperative infection (POI), which is a common, and often costly, surgical complication …