Execution of nonsense-mediated mRNA decay: what defines a substrate?
I Rebbapragada, J Lykke-Andersen - Current opinion in cell biology, 2009 - Elsevier
The nonsense-mediated mRNA decay (NMD) pathway targets mRNAs with premature
termination codons as well as a subset of normal mRNAs for rapid decay. Emerging …
termination codons as well as a subset of normal mRNAs for rapid decay. Emerging …
A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit
Mixed lineage leukemia (MLL) and its metazoan Trithorax orthologs have been linked with
the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL …
the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL …
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs
UPF1 functions in both Staufen 1 (STAU1)-mediated mRNA decay (SMD) and nonsense-
mediated mRNA decay (NMD), which we show here are competitive pathways. STAU1-and …
mediated mRNA decay (NMD), which we show here are competitive pathways. STAU1-and …
A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation
KM Kim, H Cho, K Choi, J Kim, BW Kim… - Genes & …, 2009 - genesdev.cshlp.org
During or right after mRNA export via the nuclear pore complex (NPC) in mammalian cells,
mRNAs undergo translation mediated by nuclear cap-binding proteins 80 and 20 …
mRNAs undergo translation mediated by nuclear cap-binding proteins 80 and 20 …
Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
Background Nonsense-mediated decay is a mechanism that degrades mRNAs with a
premature termination codon. That some exons have premature termination codons at …
premature termination codon. That some exons have premature termination codons at …
Homozygosity for a null allele of COL3A1 results in recessive Ehlers–Danlos syndrome
A Plancke, M Holder-Espinasse, V Rigau… - European journal of …, 2009 - nature.com
So far, mutations in the human COL3A1 gene have been associated with the predominantly
inherited Ehlers–Danlos syndrome (EDS), vascular type. Genotype–phenotype correlation …
inherited Ehlers–Danlos syndrome (EDS), vascular type. Genotype–phenotype correlation …
Evidence that the nonsense-mediated mRNA decay pathway participates in X chromosome dosage compensation in mammals
Current models of X chromosome dosage compensation are usually framed by reference to
how regulation in transcriptional level elevates the gene expression of the active X …
how regulation in transcriptional level elevates the gene expression of the active X …
Downregulation of Notch signaling by γ-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines
S Liu, S Breit, S Danckwardt, MU Muckenthaler… - Annals of …, 2009 - Springer
Activation of Notch1 signaling plays an important role in the pathogenesis of precursor T-cell
lymphoblastic leukemia (T-ALL). The Notch1 receptor is cleaved and activated via the γ …
lymphoblastic leukemia (T-ALL). The Notch1 receptor is cleaved and activated via the γ …
Quantitative sequence analysis of FBN1 premature termination codons provides evidence for incomplete NMD in leukocytes
I Magyar, D Colman, E Arnold, D Baumgartner… - Human …, 2009 - Wiley Online Library
We improved, evaluated, and used Sanger sequencing for quantification of single
nucleotide polymorphism (SNP) variants in transcripts and gDNA samples. This improved …
nucleotide polymorphism (SNP) variants in transcripts and gDNA samples. This improved …
Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells
A Tsakiridis, E Tzouanacou, A Rahman… - Nucleic acids …, 2009 - academic.oup.com
Promoterless gene trap vectors have been widely used for high-efficiency gene targeting
and random mutagenesis in embryonic stem (ES) cells. Unfortunately, such vectors are only …
and random mutagenesis in embryonic stem (ES) cells. Unfortunately, such vectors are only …