Pulmonary surfactant is a complex mixture of phospholipids (PL) and proteins (SP) that
reduce surface tension at the air–liquid interface of the alveolus. It is made up of about 70 …

Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …

Results from birth cohort and cross-sectional studies of young children with wheezing have
uncovered strong associations between both lung function and immune responses in early …

Persistence of pulmonary hypertension leading to respiratory failure in the neonate has
been recognized for 40 years since its original description by Gersony and colleagues 1 in …

Respiratory distress syndrome (RDS) is a major cause of neonatal mortality and morbidity,
especially in preterm infants. Its aetiology includes developmental immaturity of the lungs …

Abstract Prosurfactant protein C (proSP‐C) is a 197‐residue integral membrane protein, in
which the C‐terminal domain (CTC, positions 59–197) is localized in the endoplasmic …

Context.—Nonneoplastic lung diseases include a wide range of pathologic disorders from
asthma to interstitial lung disease to pulmonary hypertension. Recent advances in our …

Publisher Summary Pulmonary pathology includes a large spectrum of both neoplastic and
non-neoplastic diseases that affect the lung. Many of these are a result of the unusual …

Background: Canine pulmonary fibrosis (CPF) occurs most commonly in West Highland
White Terriers. The differing incidences of CPF among dog breeds suggest that genetic …

Respiratory problems are the most common cause of infants being admitted to a neonatal
unit and despite routine use of antenatal corticosteroids and postnatal surfactant, very …