Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis

CA Fairbanks, LS Stone, GL Wilcox - Pharmacology & therapeutics, 2009 - Elsevier
Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent
circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 …

Coexpression of α2A‐adrenergic and δ‐opioid receptors in substance P‐containing terminals in rat dorsal horn

MS Riedl, SA Schnell, AC Overland… - Journal of …, 2009 - Wiley Online Library
Agonists acting at α2‐adrenergic and opioid receptors (α2ARs and ORs, respectively) inhibit
pain transmission in the spinal cord. When coadministered, agonists activating these …

Protein kinase C mediates the synergistic interaction between agonists acting at α2-adrenergic and delta-opioid receptors in spinal cord

AC Overland, KF Kitto, AJ Chabot-Doré… - Journal of …, 2009 - Soc Neuroscience
Coactivation of spinal α2-adrenergic receptors (ARs) and opioid receptors produces
antinociceptive synergy. Antinociceptive synergy between intrathecally administered α2AR …

[HTML][HTML] Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate

R Marcon, AP Luiz, MF de Paula Werner, CS Freitas… - Brain research, 2009 - Elsevier
Previous studies from our group investigated the antinociceptive property of amyrin
octanoate, a synthetic compound derivative from natural precursor α, β-amyrin, against …

Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments

T Komatsu, M Sasaki, K Sanai, H Kuwahata… - Peptides, 2009 - Elsevier
The present study sought to examine the mechanism of substance P to modulate the
antinociceptive action of intrathecal (it) morphine in paw-licking/biting response evoked by …

[PDF][PDF] Aktywność przeciwbólowa związków wykazujących agonistyczne działanie na receptory opioidowe i tachykininowe

P Kosson - 2009 - rcin.org.pl
Serdeczne podziękowania składam promotorom niniejszej pracy Panu Profesorowi
Andrzejowi W. Lipkowskiemu za wskazanie tematu, opiekę i zaufanie przy tworzeniu tej …

[引用][C] Avaliação do efeito do ácido mirsinóico B em diferentes modelos de hipernocicepção inflamatória e neuropática persistentes em camundongos

CS Antonialli - 2009 - Universidade do Vale do Itajaí