Calcium pumps in health and disease
M Brini, E Carafoli - Physiological reviews, 2009 - journals.physiology.org
Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …
thus essential to the correct functioning of the cell machinery. They have high affinity for …
Calcium signaling and neurodegenerative diseases
I Bezprozvanny - Trends in molecular medicine, 2009 - cell.com
Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and spinocerebellar ataxias …
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and spinocerebellar ataxias …
Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice
Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant huntingtin
(htt) protein, and there are currently no effective treatments. Recently, we and others …
(htt) protein, and there are currently no effective treatments. Recently, we and others …
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models
L Menalled, BF El-Khodor, M Patry… - Neurobiology of …, 2009 - Elsevier
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known
genetic cause, knowledge that has enabled the creation of animal models using genetic …
genetic cause, knowledge that has enabled the creation of animal models using genetic …
Distinct neuroinflammatory profile in post-mortem human Huntington's disease
A Silvestroni, RLM Faull, AD Strand, T Möller - Neuroreport, 2009 - journals.lww.com
Neuroinflammation is a prominent feature of many neurodegenerative diseases, however,
little is known about neuroinflammation in Huntington's disease. We used quantitative real …
little is known about neuroinflammation in Huntington's disease. We used quantitative real …
The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies
Expansion of CAG trinucleotide repeat within the coding region of several genes results in
the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of …
the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of …
Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease
H Moffitt, GD McPhail, B Woodman, C Hobbs… - PloS one, 2009 - journals.plos.org
Background Huntington's disease (HD) is an inherited progressive neurodegenerative
disorder caused by a CAG repeat expansion in the ubiquitously expressed HD gene …
disorder caused by a CAG repeat expansion in the ubiquitously expressed HD gene …
Gene dysregulation in Huntington's disease: REST, microRNAs and beyond
R Johnson, NJ Buckley - Neuromolecular medicine, 2009 - Springer
Huntington's disease (HD) is an incurable, fatal neurodegenerative disorder that is caused
by a polyglutamine expansion in the huntingtin (Htt) protein. Neuronal death in the striatum …
by a polyglutamine expansion in the huntingtin (Htt) protein. Neuronal death in the striatum …
DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates
J Illuzzi, S Yerkes, H Parekh‐Olmedo… - Journal of …, 2009 - Wiley Online Library
Huntington's disease (HD) is a neurodegenerative disorder that follows an autosomal‐
dominant inheritance pattern. The pathogenesis of the disease depends on the degree of …
dominant inheritance pattern. The pathogenesis of the disease depends on the degree of …
A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for Huntington disease* S
C Zabel, L Mao, B Woodman, M Rohe… - Molecular & Cellular …, 2009 - ASBMB
Huntington disease (HD) is fatal in humans within 15–20 years of symptomatic disease.
Although late stage HD has been studied extensively, protein expression changes that occur …
Although late stage HD has been studied extensively, protein expression changes that occur …