Chemical mechanisms of histone lysine and arginine modifications
Histone lysine and arginine residues are subject to a wide array of post-translational
modifications including methylation, citrullination, acetylation, ubiquitination, and …
modifications including methylation, citrullination, acetylation, ubiquitination, and …
Histone modifying enzymes: structures, mechanisms, and specificities
R Marmorstein, RC Trievel - Biochimica et Biophysica Acta (BBA)-Gene …, 2009 - Elsevier
Histone modifying enzymes catalyze the addition or removal of an array of covalent
modifications in histone and non-histone proteins. Within the context of chromatin, these …
modifications in histone and non-histone proteins. Within the context of chromatin, these …
CBP/p300-mediated acetylation of histone H3 on lysine 56
Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently
been shown to have a critical role in packaging DNA into chromatin following DNA …
been shown to have a critical role in packaging DNA into chromatin following DNA …
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response
Z Sun, YE Chin, DD Zhang - Molecular and cellular biology, 2009 - Am Soc Microbiol
To maintain intracellular redox homeostasis, genes encoding many antioxidants and
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …
Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation
KC Choi, MG Jung, YH Lee, JC Yoon, SH Kwon… - Cancer research, 2009 - AACR
Because the p300/CBP-mediated hyperacetylation of RelA (p65) is critical for nuclear factor-
κB (NF-κB) activation, the attenuation of p65 acetylation is a potential molecular target for the …
κB (NF-κB) activation, the attenuation of p65 acetylation is a potential molecular target for the …
CCAAT/enhancer-binding protein β: its role in breast cancer and associations with receptor tyrosine kinases
CA Zahnow - Expert reviews in molecular medicine, 2009 - cambridge.org
The CCAAT/enhancer-binding proteins (C/EBPs) are a family of leucine-zipper transcription
factors that regulate gene expression to control cellular proliferation, differentiation …
factors that regulate gene expression to control cellular proliferation, differentiation …
Reversible acetylation of chromatin: implication in regulation of gene expression, disease and therapeutics
The eukaryotic genome is a highly dynamic nucleoprotein complex that is comprised of
DNA, histones, nonhistone proteins and RNA, and is termed as chromatin. The dynamicity of …
DNA, histones, nonhistone proteins and RNA, and is termed as chromatin. The dynamicity of …
Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin
Lysine acetyltransferases (KATs), p300 (KAT3B), and its close homologue CREB-binding
protein (KAT3A) are probably the most widely studied KATs with well documented roles in …
protein (KAT3A) are probably the most widely studied KATs with well documented roles in …
Proteome-wide prediction of acetylation substrates
A Basu, KL Rose, J Zhang, RC Beavis… - Proceedings of the …, 2009 - National Acad Sciences
Acetylation is a well-studied posttranslational modification that has been associated with a
broad spectrum of biological processes, notably gene regulation. Many studies have …
broad spectrum of biological processes, notably gene regulation. Many studies have …
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules
Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer,
diabetes, and asthma. Therefore, small molecule inhibitors and activators of HATs are being …
diabetes, and asthma. Therefore, small molecule inhibitors and activators of HATs are being …