CONTEXT: Osteoarthritis (OA) is a musculoskeletal disorder primarily affecting the older
population and resulting in chronic pain and disability. Biomechanical variables, associated …

Exercise remains an extremely popular leisure time activity in many countries throughout the
western world. It is widely promoted in the lay press as having salutory benefits for weight …

ABSTRACT OBJECTIVE To determine whether physical exercise constitutes a benefit or a
risk in the development and progression of knee osteoarthritis. QUALITY OF EVIDENCE …

Objective: To explore the natural course of knee osteoarthritis (OA) in a middle-aged
population with chronic knee pain. Methods: A population-based sample of 143 subjects …

This article will review how epidemiological studies have advanced our knowledge of both
genetic and environmental risk factors for rheumatic diseases over the past decade. The …

Abnormal tibiofemoral alignment can create loading conditions at the knee that may lead to
the initiation and progression of knee osteoarthritis (OA). The degenerative changes of the …

Nebel MB, Sims EL, Keefe FJ, Kraus VB, Guilak F, Caldwell DS, Pells JJ, Queen R, Schmitt
D. The relationship of self-reported pain and functional impairment to gait mechanics in …

OBJECTIVE: A narrative review describing the assessment of osteoarthritis (OA)
progression, and more specifically the risk factors which assist in delineating strata of …

A study was conducted to evaluate the association between age, sex, BMI, waist/hip ratio,
smoking, religion, ethnicity, education and knee osteoarthritis. Eligible subjects were …

OBJECTIVE: One of the recognized candidate genes of osteoarthritis (OA) is the ADAM
metallopeptidase domain 12 (meltrin alpha) gene. We investigated the potential role of two …