Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …

Considerable progress has been made in the treatment of patients with renal cell carcinoma,
with innovative surgical and systemic strategies revolutionising the management of this …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

Purpose Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, has
shown clinical activity in mantle cell lymphoma (MCL). We evaluated two dose regimens of …

The serine-threonine kinase mammalian target of rapamycin (mTOR) plays a major role in
the regulation of protein translation, cell growth, and metabolism. Alterations of the mTOR …

A large number of novel therapeutics is currently undergoing clinical evaluation for the
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …

The mammalian target of rapamycin (mTOR) is an intracellular serine/threonine protein
kinase positioned at a central point in a variety of cellular signaling cascades. The …

Since the discovery of rapamycin, considerable progress has been made in unraveling the
details of the mammalian target of rapamycin (mTOR) signaling network, including the …

BACKGROUND: Everolimus, an oral mammalian target of rapamycin (mTOR) inhibitor,
affects tumor growth by blocking growth factor stimulation, arresting cell cycle progression …

Background Imatinib (IM) is active in advanced chordoma. The evidence of upstream and/or
downstream mammalian target of rapamycin (mTOR) pathway activation prompted us to …