Targeting the phosphoinositide 3-kinase pathway in cancer
P Liu, H Cheng, TM Roberts, JJ Zhao - Nature reviews Drug discovery, 2009 - nature.com
Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …
that links oncogenes and multiple receptor classes to many essential cellular functions, and …
Renal cell carcinoma
BI Rini, SC Campbell, B Escudier - The Lancet, 2009 - thelancet.com
Considerable progress has been made in the treatment of patients with renal cell carcinoma,
with innovative surgical and systemic strategies revolutionising the management of this …
with innovative surgical and systemic strategies revolutionising the management of this …
PI3K/PTEN signaling in angiogenesis and tumorigenesis
BH Jiang, LZ Liu - Advances in cancer research, 2009 - Elsevier
Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …
Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
G Hess, R Herbrecht, J Romaguera… - Journal of Clinical …, 2009 - ascopubs.org
Purpose Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, has
shown clinical activity in mantle cell lymphoma (MCL). We evaluated two dose regimens of …
shown clinical activity in mantle cell lymphoma (MCL). We evaluated two dose regimens of …
Targeting the mTOR signaling network for cancer therapy
F Meric-Bernstam… - Journal of Clinical …, 2009 - ascopubs.org
The serine-threonine kinase mammalian target of rapamycin (mTOR) plays a major role in
the regulation of protein translation, cell growth, and metabolism. Alterations of the mTOR …
the regulation of protein translation, cell growth, and metabolism. Alterations of the mTOR …
Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway
A large number of novel therapeutics is currently undergoing clinical evaluation for the
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …
treatment of prostate cancer, and small molecule signal transduction inhibitors are a …
Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
RR Yuan, A Kay, WJ Berg, D Lebwohl - Journal of hematology & oncology, 2009 - Springer
The mammalian target of rapamycin (mTOR) is an intracellular serine/threonine protein
kinase positioned at a central point in a variety of cellular signaling cascades. The …
kinase positioned at a central point in a variety of cellular signaling cascades. The …
Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth
JJ Gibbons, RT Abraham, K Yu - Seminars in oncology, 2009 - Elsevier
Since the discovery of rapamycin, considerable progress has been made in unraveling the
details of the mammalian target of rapamycin (mTOR) signaling network, including the …
details of the mammalian target of rapamycin (mTOR) signaling network, including the …
A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer
RJ Amato, J Jac, S Giessinger, S Saxena, JP Willis - Cancer, 2009 - Wiley Online Library
BACKGROUND: Everolimus, an oral mammalian target of rapamycin (mTOR) inhibitor,
affects tumor growth by blocking growth factor stimulation, arresting cell cycle progression …
affects tumor growth by blocking growth factor stimulation, arresting cell cycle progression …
[HTML][HTML] Response to imatinib plus sirolimus in advanced chordoma
S Stacchiotti, A Marrari, E Tamborini, E Palassini… - Annals of …, 2009 - Elsevier
Background Imatinib (IM) is active in advanced chordoma. The evidence of upstream and/or
downstream mammalian target of rapamycin (mTOR) pathway activation prompted us to …
downstream mammalian target of rapamycin (mTOR) pathway activation prompted us to …