Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Acromegaly is a chronic disease with signs and symptoms due to growth hormone (GH)
excess. The most frequent cause of acromegaly is a GH-producing pituitary adenoma …

Context: In obesity, total IGF-I is not reduced to the degree predicted by low GH levels, and
free IGF-I levels are normal to high. Total and free IGF-I may not reflect IGF-I biological …

Context: Insulin interacts with the GH-IGF system by a reciprocal regulation of IGF-binding
proteins (IGFBP) and GH, which in turn regulate insulin sensitivity via bioactive IGF-I. This …

Growth hormone (GH) regulates somatic growth, substrate metabolism and body
composition. Its actions are elaborated through the GH receptor (GHR). GHR signalling …

BACKGROUND AND AIM: Weight gain is associated with a decline in insulin sensitivity and
a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these …

Growth hormone (GH) is a major metabolic regulator that functions by stimulating lipolysis,
preventing protein catabolism, and decreasing insulin-dependent glucose disposal …

Abstract Context: Whether GH promotes IGF-I production or lipolysis depends on nutritional
status, but the underlying mechanisms remain unknown. Objective: To investigate the impact …

Context: Experimental studies in GH-deficient patients and in healthy subjects receiving
somatostatin-infusion suggest that GH is an important regulator of substrate metabolism …

Optimal biochemical control cannot be attained by long-acting somatostatin analog
monotherapy in a large proportion of patients with acromegaly. Such therapy might result in …