Research on stem cells has progressed at a rapid pace and, as might be anticipated, the
results have generated several controversies, a few myths and a change in a major …

Hematopoietic and epithelial cancer cells express CXCR4, a seven-transmembrane G-
protein-coupled chemokine receptor. Stromal cells within the bone marrow …

Mesenchymal stem cells (MSC) are multipotent cells that differentiate into osteoblasts,
myocytes, chondrocytes and adipocytes as well as insulin-producing cells. The mechanism …

Mesenchymal stem cells (MSCs) have an inhibitory effect on tumor proliferation, but the
precise mechanisms are not fully understood. Here, we identified DKK-1 (dickkopf-1) …

Bone marrow-derived mesenchymal stem cells or multipotent mesenchymal stromal cells
(MSCs) have been shown to engraft into the stroma of several tumor types, where they …

Background Normal tissue homeostasis is maintained by dynamic interactions between
epithelial cells and their microenvironment. Disrupting this homeostasis can induce aberrant …

Background aims Mesenchymal stromal cells (MSC) have been studied intensively in
regenerative medicine. However, their therapeutic potential against tumor formation and …

In hematological malignancies, there are dynamic interactions between leukemic cells and
cells of the bone marrow microenvironment. Specific niches within the bone marrow …

Research has provided evidence that tumor growth depends on the interaction of tumor cells
with stromal cells, as already suggested in 1889 by Paget. Experimental and clinical studies …

MSCs, otherwise known as multipotent mesenchymal stromal cells, are being examined for
the treatment of autoimmune disease (AD) on the basis of their in vitro antiproliferative …