Advances in neuroimaging, developmental biology and molecular genetics have increased
the understanding of developmental disorders affecting the midbrain and hindbrain, both as …

The fine tuning of proliferation and neurogenesis, neuronal migration and differentiation and
connectivity underlies the proper development of the cerebral cortex. Mutations in genes …

Polymicrogyria is a relatively common but poorly understood defect of cortical development
characterized by numerous small gyri and a thick disorganized cortical plate lacking normal …

The critical importance of cytoskeletal function for correct neuronal migration during
development of the cerebral cortex has been underscored by the identities of germline …

Genetic microcephaly and lissencephaly are 2 of the most common brain malformations.
Each of them is a heterogeneous group of disorders caused by mutations of many different …

Objective With the largest data set of patients withLIS1-related lissencephaly, the major
cause of posteriorly predominant lissencephaly related to eitherLIS1mutation or intragenic …

Epilepsy is the most common neurological disorder affecting young people. The etiologies
are multiple and most cases are sporadic. However, some rare families with Mendelian …

Classical lissencephaly, or isolated lissencephaly sequence (ILS), and subcortical band
heterotopia (SBH) are neuronal migration disorders associated with severe mental …

The formation of the cerebral cortex requires migration of billions of cells from their birth
position to their final destination. A motile cell must have internal polarity in order to move in …

The article focuses on the features and genetic aspects of classical lissencephaly. Classical
lissencephaly is a neuronal migration disorder and magnetic resonance imaging revealed …