Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia
S Kizaka‐Kondoh, H Konse‐Nagasawa - Cancer science, 2009 - Wiley Online Library
A tumor‐specific microenvironment is characterized by hypoxia, in which oxygen tension is
considerably lower than in normal tissues. The hypoxic status of various solid tumors has …
considerably lower than in normal tissues. The hypoxic status of various solid tumors has …
The HIF-1-active microenvironment: an environmental target for cancer therapy
S Kizaka-Kondoh, S Tanaka, H Harada… - Advanced drug delivery …, 2009 - Elsevier
Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …
The Akt/mTOR pathway assures the synthesis of HIF-1α protein in a glucose-and reoxygenation-dependent manner in irradiated tumors
H Harada, S Itasaka, S Kizaka-Kondoh… - Journal of Biological …, 2009 - ASBMB
Transcriptional activity of HIF-1 (hypoxia-inducible factor-1) has been reported to be up-
regulated in solid tumors after ionizing radiation; however, the molecular mechanism …
regulated in solid tumors after ionizing radiation; however, the molecular mechanism …
Real-time imaging of HIF-1α stabilization and degradation
E Moroz, S Carlin, K Dyomina, S Burke, HT Thaler… - PloS one, 2009 - journals.plos.org
HIF-1α is overexpressed in many human cancers compared to normal tissues due to the
interaction of a multiplicity of factors and pathways that reflect specific genetic alterations …
interaction of a multiplicity of factors and pathways that reflect specific genetic alterations …
Selective killing of hypoxia-inducible factor-1–active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
S Kizaka-Kondoh, S Itasaka, L Zeng, S Tanaka… - Clinical Cancer …, 2009 - AACR
Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
H Harada, S Itasaka, Y Zhu, L Zeng, X Xie… - British journal of …, 2009 - nature.com
Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …
Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells
T Kudo, M Ueda, Y Kuge, T Mukai… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumor progression
and in the development of resistance to radiotherapy. We designed a novel fusion protein …
and in the development of resistance to radiotherapy. We designed a novel fusion protein …
Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles
In regard to gene vectors for cancer gene therapy, their percolation into the tumor tissue
should be essential for successful outcome. Here, we studied the tumor penetrability of …
should be essential for successful outcome. Here, we studied the tumor penetrability of …
Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy
G Ou, S Itasaka, L Zeng, K Shibuya, J Yi… - International Journal of …, 2009 - Elsevier
PURPOSE: To study the relationship between the hypoxia-inducible factor-1 (HIF-1) activity
level after bevacizumab treatment and the antitumor effects of radiation to determine the …
level after bevacizumab treatment and the antitumor effects of radiation to determine the …
Imaging and targeting of the hypoxia-inducible factor 1-active microenvironment
S Kizaka-Kondoh, S Tanaka… - Journal of toxicologic …, 2009 - jstage.jst.go.jp
Human solid tumors contain hypoxic regions that have considerably lower oxygen tension
than normal tissues. They are refractory to radiotherapy and anticancer chemotherapy …
than normal tissues. They are refractory to radiotherapy and anticancer chemotherapy …