Enabling a systems biology approach to immunology: focus on innate immunity

JL Gardy, DJ Lynn, FSL Brinkman, REW Hancock - Trends in immunology, 2009 - cell.com
Immunity is not simply the product of a series of discrete linear signalling pathways; rather it
is comprised of a complex set of integrated responses arising from a dynamic network of …

Human protein reference database—2009 update

TS Keshava Prasad, R Goel, K Kandasamy… - Nucleic acids …, 2009 - academic.oup.com
Abstract Human Protein Reference Database (HPRD—http://www. hprd. org/), initially
described in 2003, is a database of curated proteomic information pertaining to human …

[HTML][HTML] Human protein reference database—2009 update

TSK Prasad, R Goel, K Kandasamy… - Nucleic acids …, 2009 - ncbi.nlm.nih.gov
Abstract Human Protein Reference Database (HPRD—http://www. hprd. org/), initially
described in 2003, is a database of curated proteomic information pertaining to human …

Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology

TSK Prasad, K Kandasamy, A Pandey - Reverse Chemical Genetics …, 2009 - Springer
Although high-throughput technologies used in biology have resulted in the accumulation of
vast amounts of data in the literature, it is becoming difficult for individual investigators to …

Cytoscape: a community-based framework for network modeling

S Killcoyne, GW Carter, J Smith, J Boyle - Protein networks and pathway …, 2009 - Springer
Cytoscape is a general network visualization, data integration, and analysis software
package. Its development and use has been focused on the modeling requirements of …

Primary biliary cirrhosis is associated with altered hepatic microRNA expression

KA Padgett, RY Lan, PC Leung, A Lleo, K Dawson… - Journal of …, 2009 - Elsevier
MicroRNAs (miRNAs) are small RNA molecules that negatively regulate protein coding
gene expression and are thought to play a critical role in many biological processes …

Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin β

PC Echeverría, G Mazaira, A Erlejman… - … and cellular biology, 2009 - Am Soc Microbiol
Glucocorticoid receptor (GR) is cytoplasmic in the absence of ligand and localizes to the
nucleus after steroid binding. Previous evidence demonstrated that the hsp90-based …

[HTML][HTML] Layered functional network analysis of gene expression in human heart failure

W Zhu, L Yang, Z Du - PloS one, 2009 - journals.plos.org
Background Although dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF),
the mechanism underlying DCM is not well understood. Previously, it has been …

利用已知基因傳遞機制及蛋白質交互作用圖譜來開發新的基因互動途徑

翁小涵 - 2009 - tdr.lib.ntu.edu.tw
近年來, 基因晶片(microarray) 的數據分析已經從傳統上僅利用統計分析的方法,
轉向加入更多已知基因功能性註解來協助分析. 生物反應路徑分析法(pathway analysis) …

[PDF][PDF] PNmerger: a cytoscape plugin to merge biological pathways and protein interaction networks

HC Sun, D Li, J Wang, ZY LIU, YP ZHU… - … in Biochemistry and …, 2009 - researchgate.net
PNmerger (a biological Pathway and protein Network merger) is a java based plugin for the
widely used open source Cytoscape molecular interaction viewer. For a protein interaction …