Apoptosis is a conserved homeostatic process critical for organ and tissue morphogenesis,
development, and senescence. This form of programmed cell death also participates in the …

Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of
normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic …

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen
overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most …

Drug-induced liver injury is a significant and still unresolved clinical problem. Limitations to
knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic …

Interindividual variability in response to chemicals and drugs is a common regulatory
concern. It is assumed that xenobiotic-induced adverse reactions have a strong genetic …

Matrine (Mat), a component extracted from Sophora flavescens Ait, has a wide spectrum of
pharmacological effects. Glycyrrhizin (Gly), a major active constituent of licorice (Glycyrrhiza …

Introduction Acetaminophen (APAP) toxicity is the most common cause of acute liver failure
in the US and Europe. Massive hepatocyte necrosis is the predominant feature of APAP …

Toxicogenomic studies are increasingly used to uncover potential biomarkers of adverse
health events, enrich chemical risk assessment, and to facilitate proper identification and …

This review aims to give an update of the field of the hepatic sinusoid, supported by
references to presentations given at the 14th International Symposium on Cells of the …

We investigated the regulation of antioxidant system under acetaminophen (AAP) toxicity.
Twelve male New Zealand rabbits were divided into two groups with the following …