Methods This paper arose from an extensive literature review undertaken in developing the
Canadian Healthy Infant Longitudinal Development (CHILD) study, a multicentre national …

Asthma has emerged as an important public health problem in many Latin American
countries over the past decade. In Brazil and Costa Rica, the prevalence of asthma and …

Background Attacks of wheezing induced by upper respiratory viral infections are common
in preschool children between the ages of 10 months and 6 years. A short course of oral …

BACKGROUND: The inability to measure IgE-based sensitivity to all allergens has limited
our understanding of what portion of asthma is related to IgE. Total IgE measurement can …

A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical
modification of pseurotin A was performed. Structure–activity relationship studies of …

Rationale: Asthma is associated with increased airway responsiveness (AR), but the age
when this relationship becomes established is not clear. The present study tested the …

Studies performed using cultured cells indicate that IgE functions not only to trigger
degranulation of mast cells following allergen exposure, but also to enhance their survival …

Understanding the mechanisms involved in respiratory tolerance to inhaled allergens could
potentially result in improved therapies for asthma and allergic diseases. Airway …

Background: Serum immunoglobulin E (IgE) level is recognized to be under strong genetic
control, but the causal and susceptibility genes remain to be identified. We sought to …

Background Occupational exposure to chemicals is an important cause of asthma. Recent
studies indicate that IgE antibodies enhance sensitization to chemicals in the skin. Objective …