Sepsis is a complex and heterogeneous syndrome defined by the systemic inflammatory
response to infection. 1 Development of organ failure leads to severe sepsis. Septic shock is …

Introduction 3. Animal models of sepsis 3.1. Exogenous administration of a toxin 3.2.
Intravenous infusion of a viable pathogen 3.3. Administration of fecal material or live …

Severe sepsis is one of the leading causes of death worldwide. High mortality rates in sepsis
are frequently associated with neutropenia. Despite the central role of neutrophils in innate …

Interferon-γ (IFN-γ) and tumor necrosis factor (TNF) are essential cytokines for successful
clearance of microbial infections. Activation of macrophages by synergistic effects of these …

In the acute-care setting, it is widely accepted that elderly patients have increased morbidity
and mortality compared with young healthy patients. The reasons for this, however, are …

Sepsis is still a major cause of mortality in the intensive critical care unit and results from an
overwhelming immune response to the infection. TNF signaling pathway plays a central role …

Background: Resident tissue macrophages exert important functions during severe systemic
infection and contribute to changes in local as well as systemic immune responses. Alveolar …

Although it is generally accepted that early defense mechanisms are controlled by cells of
the innate immune system, T cells were found to be crucial for host resistance against acute …

目的研究羟乙基淀粉(HES) 130/0.4 行中度急性高容量血液稀释(AHH) 对脓毒症兔肺脏的影响,
并探讨其可能机制. 方法取健康新西兰兔30 只, 随机分为模型组, 假手术组, 治疗组, 每组10 只 …

炎症是机体组织对感染反应的基本进程. 免疫系统的激活通常可以将微生物病原体清除,
当炎症反应消退后, 免疫系统将恢复原有的平衡. 然而这一正常的过程可能被疾病所扰乱. 因此 …