Function of Nod‐like receptors in microbial recognition and host defense
L Franchi, N Warner, K Viani… - Immunological reviews, 2009 - Wiley Online Library
Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …
intracellular proteins that play a critical role in the regulation of the host innate immune …
Toll-like receptors and cancer
S Rakoff-Nahoum, R Medzhitov - Nature reviews cancer, 2009 - nature.com
Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known
for their role in host defence from infection. Emerging evidence also suggests that TLRs …
for their role in host defence from infection. Emerging evidence also suggests that TLRs …
Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
FG Bauernfeind, G Horvath, A Stutz… - The Journal of …, 2009 - journals.aai.org
The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels.
Pattern recognition and cytokine receptors control pro-IL-1β transcription whereas …
Pattern recognition and cytokine receptors control pro-IL-1β transcription whereas …
mTOR regulates memory CD8 T-cell differentiation
K Araki, AP Turner, VO Shaffer, S Gangappa, SA Keller… - Nature, 2009 - nature.com
Memory CD8 T cells are a critical component of protective immunity, and inducing effective
memory T-cell responses is a major goal of vaccines against chronic infections and …
memory T-cell responses is a major goal of vaccines against chronic infections and …
RIG-I-dependent sensing of poly (dA: dT) through the induction of an RNA polymerase III–transcribed RNA intermediate
RNA is sensed by Toll-like receptor 7 (TLR7) and TLR8 or by the RNA helicases LGP2,
Mda5 and RIG-I to trigger antiviral responses. Much less is known about sensors for DNA …
Mda5 and RIG-I to trigger antiviral responses. Much less is known about sensors for DNA …
A cell biological view of Toll-like receptor function: regulation through compartmentalization
An emerging paradigm in innate immune signalling is that cell biological context can
influence the outcome of a ligand–receptor interaction. In this Review we discuss how Toll …
influence the outcome of a ligand–receptor interaction. In this Review we discuss how Toll …
CD14 and toll-like receptors 2 and 4 are required for fibrillar Aβ-stimulated microglial activation
EG Reed-Geaghan, JC Savage, AG Hise… - Journal of …, 2009 - Soc Neuroscience
Microglia are the brain's tissue macrophages and are found in an activated state
surrounding β-amyloid plaques in the Alzheimer's disease brain. Microglia interact with …
surrounding β-amyloid plaques in the Alzheimer's disease brain. Microglia interact with …
Viruses and thyroiditis: an update
R Desailloud, D Hober - Virology journal, 2009 - Springer
Viral infections are frequently cited as a major environmental factor involved in subacute
thyroiditis and autoimmune thyroid diseases This review examines the data related to the …
thyroiditis and autoimmune thyroid diseases This review examines the data related to the …
Pathogen recognition in the innate immune response
Immunity against microbial pathogens primarily depends on the recognition of pathogen
components by innate receptors expressed on immune and non-immune cells. Innate …
components by innate receptors expressed on immune and non-immune cells. Innate …
An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
Candida albicans is an opportunistic fungal pathogen causing life-threatening mucosal and
systemic infections in immunocompromised humans. Using a murine model of mucosal …
systemic infections in immunocompromised humans. Using a murine model of mucosal …