Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …

Aim: Given the growing interest in the study of first‐episode psychosis, clinical and research
programmes would benefit from a conceptual clarification of how to operationalize 'first …

Animal models play a central role in all areas of biomedical research. The process of animal
model building, development and evaluation has rarely been addressed systematically …

A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide
linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected …

BackgroundIt has been suggested that some psychotic symptoms reflect 'aberrant salience',
related to dysfunctional reward learning. To test this hypothesis we investigated whether …

Molecular imaging studies have generated important in vivo insights into the etiology of
schizophrenia and treatment response. This article first reviews the PET and SPECT …

Epidemiological research suggests that both an individual's genes and the environment
underlie the pathophysiology of schizophrenia. Molecular mechanisms mediating the …

BACKGROUND: The duration of untreated psychosis (DUP) is defined as the period
between the onset of symptoms of psychosis and the start of antipsychotic treatment. Delay …

The article summarizes the process used to distill schizophrenia science into 22 facts. These
facts consist of 6 basic facts, 3 etiological facts, 6 pharmacological and treatment facts, 5 …

Previous surveys found a large (> 10-fold) variation in schizophrenia prevalence at different
geographic sites and a tendency for prevalence to increase with latitude. We conducted …