How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Modeling of human neuropsychiatric disorders in animals is extremely challenging given the
subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests …

Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …

Strong evidence suggests that rare mutations of severe effect are responsible for a
substantial portion of complex human disease. Evolutionary forces generate vast genetic …

A pressing need for interrater reliability in the diagnosis of mental disorders emerged during
the mid-twentieth century, prompted in part by the development of diverse new treatments …

Recent genetic studies reinforce the view that current approaches to the diagnosis and
classification of major psychiatric illness are inadequate. These findings challenge the …

The hippocampal formation is one of the most extensively studied regions of the brain, with
well-described anatomy and basic physiology; moreover, aspects of human memory …

Delusions are the false and often incorrigible beliefs that can cause severe suffering in
mental illness. We cannot yet explain them in terms of underlying neurobiological …

Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable disorder,
but specific genetic factors underlying risk remain elusive. To assess the role of structural …

This article introduces the reader to the genetics of schizophrenia: its background; the status
of a variety of genetic findings; new developments (which are many since the last review) 1; …