Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Colorectal cancer is a heterogeneous disease. There are three main pathways to colorectal
cancer: the chromosomal instability pathway, the CpG island methylator phenotype pathway …

Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a
heterogeneous disease, with proximal and distal CRCs showing multiple biological and …

BACKGROUND & AIMS: There is evidence that serrated polyps (serrated adenomas and
hyperplastic polyps) have different malignant potential than traditional adenomas. We used …

Colonic cancers with a serrated morphology have been proposed to comprise a molecularly
distinct tumor entity following an alternative pathway of genetic alterations independently of …

It is well known that adenomas represent the morphologically categorised precursor of the
vast majority of colorectal cancers. Only few adenomas actually develop invasive cancer …

Until recently, two major types of colorectal epithelial polyps were distinguished: the
adenoma and the hyperplastic polyp. While adenomas—because of their cytological atypia …

Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal
cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or …

There are two major molecular pathways to sporadic colorectal cancer, the chromosomal
instability (CIN) and the CpG island methylator phenotype (CIMP) pathways. This study …

The pathogenesis and risk of malignancy of traditional serrated adenomas (TSAs) are
unclear. In North America, TSAs are relatively uncommon, occur mainly in the left colon, and …