Inflammation and oxidative stress contribute to the pathology of many diseases, but specific
therapeutic targets remain elusive. Oxidative stress, generated by excessive reactive oxygen …

2250 SATOH K et al. tion factor in protein folding and assembly. The first demonstration of
this activity in vitro was delaying the maturation of collagen by blocking PPIase activity with …

Complicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men.
Ang II–dependent TGF-β activity promotes aortic aneurysm progression in experimental …

Rationale: Angiotensin-converting enzyme (ACE) 2 opposes the actions of angiotensin
(Ang) II by degrading it to Ang 1-7. Objective: Given the important role of Ang II/Ang 1-7 in …

AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms)
through multiple proposed mechanisms, including chemotaxis. Therefore, we determined …

BACKGROUND: A modest (41%) reduction in abdominal aortic aneurysm (AAA) growth rate
is likely to delay AAA-related events (surgery or rupture) by 5 years, making the notion of …

Aortic aneurysms are common among the elderly population. A large majority of aortic
aneurysms are located at two distinct aneurysm-prone regions, the abdominal aorta and …

The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the
initiation and progression of atherosclerosis, thereby contributing to development of …

Current therapies for diseases of heart muscle (cardiomyopathy) and aorta (aortopathy)
include inhibitors of the renin-angiotensin system, β-adrenergic antagonists, and the statin …

Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted
phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a …