Alzheimer disease is characterized by the accumulation of abnormally folded protein
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …

Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The
abnormal parenchymal accumulation of β‐amyloid (Aβ) is associated with inflammatory …

J. Neurochem.(2010) 115, 47–57. Abstract The brain steady state level of β‐amyloid (Aβ) is
determined by the balance between its production and removal, the latter through egress …

PICALM, the gene encoding phosphatidylinositol-binding clathrin assembly (picalm) protein,
was recently shown to be associated with risk of Alzheimer disease (AD). Picalm is a key …

We recently found that insoluble Aβ increases, but soluble Aβ decreases with age in normal
brains. We now report the changes in activities of β‐secretase (BACE‐1) and Aβ‐degrading …

Introduction• Targets and ongoing research‐NGF‐Neurotrophic function of NGF‐Levels of
NGF in AD‐Role of NGF in AD‐NGF as a therapeutic agent‐Development of NGF gene …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that currently affects
millions of Americans. There is no cure at present and no real long-term hope for patients …

Alzheimer's disease (AD) is a complex disorder of the central nervous system that affects an
increasing number of people worldwide due to the overall aging of the human population. In …

The accumulation of the amyloid-beta peptide (Aβ) continues to emerge as a central factor in
Alzheimer's disease (AD). In recent years attention has been drawn to clearance …

More than 5 million people in the United States are afflicted with Alzheimer disease, a
condition that is the seventh leading cause of death in the nation. Lacking definitive disease …