Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the
burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …

TP53 mutation occurs in 50–75% of human pancreatic ductal adenocarcinomas (PDAC)
following an initiating activating mutation in the KRAS gene. These p53 mutations frequently …

The KRAS gene (Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that
encodes a small GTPase transductor protein called KRAS. KRAS is involved in the …

Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT
mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a …

Discussions of eosinophils are often descriptions of end‐stage effector cells with destructive
capabilities mediated predominantly by released cytotoxic cationic granule proteins …

OBJECTIVE Conditional gene targeting has been extensively used for in vivo analysis of
gene function in β-cell biology. The objective of this study was to examine whether mouse …

Therapeutic applications of microRNA (miRNA) in KRAS-driven pancreatic cancers might be
valuable, but few studies have explored this area. Here, we report that miR-96 directly …

Although activating mutations in RAS oncogenes are known to result in aberrant signaling
through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program …

Background: Pancreatic ductal adenocarcinoma (PDAC) has the poorest overall prognosis
among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly …