Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection
S Raimondi, AB Lowenfels, AM Morselli-Labate… - Best practice & research …, 2010 - Elsevier
Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the
burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute …
burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute …
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
JP Morton, P Timpson, SA Karim… - Proceedings of the …, 2010 - National Acad Sciences
TP53 mutation occurs in 50–75% of human pancreatic ductal adenocarcinomas (PDAC)
following an initiating activating mutation in the KRAS gene. These p53 mutations frequently …
following an initiating activating mutation in the KRAS gene. These p53 mutations frequently …
Clinical relevance of KRAS in human cancers
S Jančík, J Drábek, D Radzioch… - BioMed Research …, 2010 - Wiley Online Library
The KRAS gene (Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that
encodes a small GTPase transductor protein called KRAS. KRAS is involved in the …
encodes a small GTPase transductor protein called KRAS. KRAS is involved in the …
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
JP Morris, DA Cano, S Sekine… - The Journal of …, 2010 - Am Soc Clin Investig
Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT
mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a …
mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a …
Eosinophils in health and disease: the LIAR hypothesis
JJ Lee, EA Jacobsen, MP McGarry… - Clinical & …, 2010 - Wiley Online Library
Discussions of eosinophils are often descriptions of end‐stage effector cells with destructive
capabilities mediated predominantly by released cytotoxic cationic granule proteins …
capabilities mediated predominantly by released cytotoxic cationic granule proteins …
Conditional gene targeting in mouse pancreatic β-cells: analysis of ectopic Cre transgene expression in the brain
B Wicksteed, M Brissova, W Yan, DM Opland… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Conditional gene targeting has been extensively used for in vivo analysis of
gene function in β-cell biology. The objective of this study was to examine whether mouse …
gene function in β-cell biology. The objective of this study was to examine whether mouse …
miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer
S Yu, Z Lu, C Liu, Y Meng, Y Ma, W Zhao, J Liu, J Yu… - Cancer research, 2010 - AACR
Therapeutic applications of microRNA (miRNA) in KRAS-driven pancreatic cancers might be
valuable, but few studies have explored this area. Here, we report that miR-96 directly …
valuable, but few studies have explored this area. Here, we report that miR-96 directly …
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
OA Kent, RR Chivukula, M Mullendore… - Genes & …, 2010 - genesdev.cshlp.org
Although activating mutations in RAS oncogenes are known to result in aberrant signaling
through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program …
through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program …
MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions
MC Du Rieu, J Torrisani, J Selves, T Al Saati… - Clinical …, 2010 - academic.oup.com
Background: Pancreatic ductal adenocarcinoma (PDAC) has the poorest overall prognosis
among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly …
among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly …