Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold
B Findlay, GG Zhanel, F Schweizer - Antimicrobial agents and …, 2010 - Am Soc Microbiol
Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse
class of antibacterial agents currently validated in preclinical and clinical settings for the …
class of antibacterial agents currently validated in preclinical and clinical settings for the …
[HTML][HTML] Insight into invertebrate defensin mechanism of action: oyster defensins inhibit peptidoglycan biosynthesis by binding to lipid II
P Schmitt, M Wilmes, M Pugnière, A Aumelas… - Journal of Biological …, 2010 - ASBMB
Three oyster defensin variants (Cg-Defh1, Cg-Defh2, and Cg-Defm) were produced as
recombinant peptides and characterized in terms of activities and mechanism of action. In …
recombinant peptides and characterized in terms of activities and mechanism of action. In …
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption
Defensins are cationic and disulfide-bonded host defense proteins of many animals that
target microbial cell membranes. Elucidating the three-dimensional structure, dynamics, and …
target microbial cell membranes. Elucidating the three-dimensional structure, dynamics, and …
Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and …
KS Brinch, PM Tulkens, F Van Bambeke… - Journal of …, 2010 - academic.oup.com
Objectives Staphylococcus aureus survives inside eukaryotic cells. Our objective was to
assess the activity of NZ2114, a novel peptidic antibiotic, against intracellular S. aureus in …
assess the activity of NZ2114, a novel peptidic antibiotic, against intracellular S. aureus in …
[HTML][HTML] A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct …
B López-García, M Gandía, A Muñoz, L Carmona… - BMC microbiology, 2010 - Springer
Background The mechanism of action of antimicrobial peptides (AMP) was initially
correlated with peptide membrane permeation properties. However, recent evidences …
correlated with peptide membrane permeation properties. However, recent evidences …
[HTML][HTML] The heme sensing response regulator HssR in Staphylococcus aureus but not the homologous RR23 in Listeria monocytogenes modulates susceptibility to …
LE Thomsen, CT Gottlieb, S Gottschalk, TT Wodskou… - BMC microbiology, 2010 - Springer
Abstract Background Host defence peptides (HDPs), also known as antimicrobial peptides
(AMPs), have emerged as potential new therapeutics and their antimicrobial spectrum …
(AMPs), have emerged as potential new therapeutics and their antimicrobial spectrum …
Plectasin–ein neues Peptidantibiotikum mit hohem therapeutischem Potential
J Schmitz, U Holzgrabe - Pharmazie in unserer Zeit, 2010 - Wiley Online Library
Schon länger ist bekannt, dass niedere Tiere und höhere Pflanzen endogene
Peptidantibiotika exprimieren, die aktiv gegen Bakterien, Pilze und Viren sind. Einige dieser …
Peptidantibiotika exprimieren, die aktiv gegen Bakterien, Pilze und Viren sind. Einige dieser …
Antibiotic leads challenge conventional wisdom
M Elsner - Nature biotechnology, 2010 - nature.com
Two recent papers in Science 1, 2 provide surprising twists to the conventional views on
how members of two extensively studied classes of molecules exert their effects. Whereas …
how members of two extensively studied classes of molecules exert their effects. Whereas …