Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action
V Christen, S Hickmann, B Rechenberg, K Fent - Aquatic toxicology, 2010 - Elsevier
Widespread occurrence of traces of pharmaceuticals (ng/L to μg/L) has been reported in
aquatic systems. However, their effects on the environment and their environmental risks …
aquatic systems. However, their effects on the environment and their environmental risks …
Pharmaceuticals in the aquatic environment: steroids and anti-steroids as high priorities for research
TJ Runnalls, L Margiotta-Casaluci… - … and Ecological Risk …, 2010 - Taylor & Francis
Many human pharmaceuticals, with many modes of action, are present in the aquatic
environment. It is very difficult to know which of these might pose a threat to aquatic …
environment. It is very difficult to know which of these might pose a threat to aquatic …
Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and …
Over recent years, human pharmaceuticals have been detected in the aquatic environment.
This, combined with the fact that many are (by design) biologically active compounds, has …
This, combined with the fact that many are (by design) biologically active compounds, has …
Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals
JP Berninger, BW Brooks - Toxicology Letters, 2010 - Elsevier
Comparative pharmacology and toxicology approaches with fish models provide important
linkages between the biomedical and environmental sciences. Because chronic fish …
linkages between the biomedical and environmental sciences. Because chronic fish …
Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas)
GH Panter, TH Hutchinson, KS Hurd, J Bamforth… - Aquatic toxicology, 2010 - Elsevier
A fish full life-cycle (FFLC) is the most comprehensive test to determine reproductive toxicity
of chemicals to fish and this is likely to apply equally to endocrine active chemicals (EACs) …
of chemicals to fish and this is likely to apply equally to endocrine active chemicals (EACs) …