Excitation-contraction coupling and minor triadic proteins in low-frequency fatigue

EM Balog - Exercise and sport sciences reviews, 2010 - journals.lww.com
Skeletal muscle fatigue has been defined as the transient work-induced inability to maintain
the expected or required force or power output. The potential mechanisms underlying the …

ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel

R Barro-Soria, F Aldehni, J Almaça, R Witzgall… - … -European Journal of …, 2010 - Springer
Abstract Bestrophins form Ca 2+-activated Cl− channels and regulate intracellular Ca 2+
signaling. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER) …

[HTML][HTML] Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel

SJ Pitt, KH Park, M Nishi, T Urashima, S Aoki… - Biophysical journal, 2010 - cell.com
The presence of a sarcoplasmic reticulum (SR) K+-selective ion-channel has been known
for> 30 years yet the molecular identity of this channel has remained a mystery. Recently, an …

[HTML][HTML] Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle

X Zhao, D Yamazaki, KH Park, S Komazaki… - Journal of Biological …, 2010 - ASBMB
The sarcoplasmic reticulum (SR) of skeletal muscle contains K+, Cl−, and H+ channels may
facilitate charge neutralization during Ca 2+ release. Our recent studies have identified …

Single particle reconstruction of membrane proteins: a tool for understanding the 3D structure of disease-related macromolecules

K Mio, Y Maruyama, T Ogura, M Kawata… - Progress in biophysics …, 2010 - Elsevier
Membrane proteins play important roles in cell functions such as neurotransmission, muscle
contraction, and hormone secretion, but their structures are mostly undetermined. Several …

Endoplasmic reticulum calcium homeostasis and neuronal pathophysiology of stroke

A Verkhratsky - New Strategies in Stroke Intervention: Ionic …, 2010 - Springer
Endoplasmic reticulum (ER) formed by the endomembrane is arguably the largest
intracellular organelle. The ER is present in all types of neural cell, in neurones and in glia …

IP3 Receptors

CW Taylor, Z Ding - Handbook of Cell Signaling, 2010 - Elsevier
Publisher Summary Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) are large proteins that
play an important role in linking the many receptors. They are also important in mediating …

[图书][B] Local vs. global ryanodine receptor mediated diastolic calcium release in adult mammalian ventricular myocytes

DJ Santiago - 2010 - search.proquest.com
The Ca 2+ release units of ventricular myocytes are clusters of Ca 2+ release channels
(ryanodine receptors; RyRs) in the sarcoplasmic reticulum (SR) membrane, which arrange …

Functional Characterization of Ion Channels with a Crucial Role in Cystic Fibrosis: Regulation of Epithelial Na+ Channel (ENaC) and Ca2+-Activated Cl-Channels …

JCP Almaça - 2010 - search.proquest.com
Cystic Fibrosis (CF) is a genetic disease leading to a progressive major pulmonary
dysfunction and caused by mutations in the gene encoding the Cystic Fibrosis …

小胞体Ca2+´ 放出におけるTRIC チャネルの生理的役割

山崎大樹, 山本伸一郎, 竹島浩 - 日本薬理学雑誌, 2010 - jstage.jst.go.jp
抄録 細胞内 Ca 2+ ストアである小胞体からの Ca 2+ 放出は, リアノジン受容体と IP 3 受容体の 2
種の Ca 2+ 放出チャネルにより仲介され, 様々な細胞機能を制御する. しかしながら, 小胞体 Ca 2+ …