Mitochondrial diseases frequently manifest neuro-ophthalmologic symptoms and signs.
Because of the predilection of mitochondrial disorders to involve the optic nerves …

Age-related neurodegenerative diseases are associated with mild impairment of oxidative
metabolism and accumulation of abnormal proteins. Within the cell, the mitochondria …

Additional neurological features have recently been described in seven families transmitting
pathogenic mutations in OPA1, the most common cause of autosomal dominant optic …

Postmortem, genetic, brain imaging, and peripheral cell studies all support decreased
mitochondrial activity as a factor in the manifestation of Bipolar Disorder (BD). Because …

Mitochondria in mammalian cells are visualized as a network or as filaments that undergo
continuous changes in shape and in localization within the cells. These changes are a …

We investigated two male infant patients who were given a diagnosis of progressive
mitochondrial encephalomyopathy on the basis of clinical, biochemical, and morphological …

Apoptosis-inducing factor (AIF) was initially discovered as a caspase-independent death
effector. AIF fulfills its lethal function after its release from mitochondria and its translocation …

Pathogenic OPA1 mutations cause autosomal dominant optic atrophy (DOA), a condition
characterized by the preferential loss of retinal ganglion cells and progressive optic nerve …

Exercise induced adaptations in muscle are highly specific and dependent upon the type of
exercise, as well as its frequency, intensity, and duration. Mitochondria are highly dynamic …

Mitochondrial morphology varies according to cell type and cellular context from an
interconnected filamentous network to isolated dots. This morphological plasticity depends …