Background Sensory information from the viscera, including the gastrointestinal (GI) tract, is
transmitted through the afferent vagus via a glutamatergic synapse to neurons of the nucleus …

Postnatal deficits in brain-derived neurotrophic factor (BDNF) are thought to contribute to
pathogenesis of Rett syndrome (RTT), a progressive neurodevelopmental disorder caused …

TRPV1 receptors feature prominently in nociception of spinal primary afferents but are also
expressed in unmyelinated cranial visceral primary afferents linked to homeostatic …

Using combined morphological and electrophysiological approaches, we have determined
the composition of inhibitory synapses of the nucleus tractus solitarii (NTS), a brainstem …

GABAergic neurones are interspersed throughout the nucleus tractus solitarii (NTS), and
their tonic activity is crucial to the maintenance of cardiorespiratory homeostasis. However …

The rostral nucleus of the solitary tract (rNST) plays a pivotal role in taste processing. The
rNST contains projection neurons and interneurons that differ in morphology and intrinsic …

In prior studies, we found that activation of cannabinoid-1 receptors in the nucleus tractus
solitarii (NTS) prolonged baroreflex-induced sympathoinhibition in rats. In many regions of …

Hyperthermic prolongation of the laryngeal chemoreflex (LCR) in decerebrate piglets is
prevented or reversed by GABAA receptor antagonists and adenosine A2A (Ad‐A2A) …

The selective γ-aminobutyric acid B-subtype receptor agonist baclofen activates both
presynaptic and postsynaptic receptors in the brain. Microinjection of baclofen into the …

The solitary tract nucleus (NTS) is the termination site for cranial visceral afferents–
peripheral primary afferent neurons which differ by phenotype (eg myelinated and …