Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Retrospective studies that may be impractical to confirm prospectively suggest that diabetics
treated with metformin have a substantially reduced cancer burden compared with other …

Transforming Growth Factor-b (TGFb) is a major driving force of the Epithelial-to-
Mesenchymal (EMT) genetic program, which becomes overactive in the pathophysiology of …

The new incretin-based therapies, dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon
like peptide 1 (GLP1) receptor agonists are widely used for the treatment of type 2 diabetes …

Pathophysiological conditions characterised by hyperinsulinaemia, such as obesity and
physical inactivity, are recognised risk factors for the development of several cancer types. 1 …

Diabetes and cancer are common conditions, and their co-diagnosis in the same individual
is not infrequent. A link between the two conditions has been postulated for almost 80 years …

From time to time workers in apparently unrelated fields look sideways to discover that
others are working on the same problem from a different angle. This happened recently …

Diabetes mellitus is a growing public health concern in the US and worldwide. Insulin
therapy is the cornerstone of diabetes therapy, and the use of basal insulins will increase as …

Connections between cancer and metabolic diseases may consist in the complex network of
interactions among a common set of biomolecules. By applying singularity and bifurcation …

Theories on a connection between diabetes, obesity, and cancer have existed for over a
century. In 1910, despite their elusive etiologies, Maynard hypothesized that a correlation …