Epigenetic modifications of the genome are generally stable in somatic cells of multicellular
organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on …

Epigenetic modifications are widely accepted as playing a critical role in the regulation of
gene expression and thereby contributing to the determination of the phenotype of …

Epigenetic information can be inherited through the mammalian germline and represents a
plausible transgenerational carrier of environmental information. To test whether …

Germ cell development is controlled by unique gene expression programs and involves
epigenetic reprogramming of histone modifications and DNA methylation. The central event …

Embryonic development is regulated by both genetic and epigenetic mechanisms, with
nearly all DNA-templated processes influenced by chromatin architecture. Sequence …

Individual cell fate decisions can vary according to changes in gene expression in response
to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during …

The Polycomb group (PcG) system represses the transcription of important developmental
regulators and perpetuates this repression across multiple cell divisions. Inputs from outside …

Since Mendel, studies of phenotypic variation and disease risk have emphasized
associations between genotype and phenotype among affected individuals in families and …

Here, we summarize current knowledge about epigenetic reprogramming during
mammalian preimplantation development, as well as the potential mechanisms driving …

Mammals, like all multicellular organisms, develop from a single cell—the totipotent zygote.
During preimplantation development and subsequent development in utero, over 200 …