Endogenous toll‐like receptor ligands and their biological significance

L Yu, L Wang, S Chen - Journal of cellular and molecular …, 2010 - Wiley Online Library
Introduction• TLR signalling• Endogenous TLR ligands• Biological significance of signalling
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

E Neumann, S Lefèvre, B Zimmermann, S Gay… - Trends in molecular …, 2010 - cell.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial
hyperplasia and progressive joint destruction. Rheumatoid arthritis synovial fibroblasts …

State-of-the-art: rheumatoid arthritis

IB McInnes, JR O'Dell - Annals of the rheumatic diseases, 2010 - ard.bmj.com
The understanding of the pathogenesis and optimal therapeutics for rheumatoid arthritis
(RA) has advanced remarkably over the last decade. This review highlights these key …

Innate immunity and rheumatoid arthritis

A Gierut, H Perlman, RM Pope - Rheumatic Disease …, 2010 - rheumatic.theclinics.com
Although environmental insults such as smoking have been implicated in the initiation of
rheumatoid arthritis (RA) in patients who express the shared epitope, the understanding of …

TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury

WP Pulskens, E Rampanelli, GJ Teske… - Journal of the …, 2010 - journals.lww.com
Toll-like receptors (TLRs) can orchestrate an inflammatory response upon activation by
pathogen-associated motifs and release of endogenous stress ligands during tissue injury …

[HTML][HTML] Poly (I: C) drives type I IFN-and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis

GA Farina, MR York, M Di Marzio, CA Collins… - Journal of Investigative …, 2010 - Elsevier
Immune activation of fibrosis likely has a crucial role in the pathogenesis of systemic
sclerosis (SSc). The aim of this study was to better understand the innate immune regulation …

Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis

G Alsaleh, L Sparsa, E Chatelus, M Ehlinger… - Arthritis research & …, 2010 - Springer
Abstract Introduction Interleukin-32 (IL-32) is a recently described cytokine that is a strong
inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, and …

[HTML][HTML] Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis

QQ Huang, RM Pope - Journal of leukocyte biology, 2010 - ncbi.nlm.nih.gov
Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and
atherosclerosis - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats

L Meng, W Zhu, C Jiang, X He, W Hou, F Zheng… - Arthritis research & …, 2010 - Springer
Abstract Introduction Toll-like receptors (TLRs) are involved in both innate and adaptive
immune responses and are likely to play a complex role in the pathogenesis of human …

The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant‐induced arthritis in rats

E Yannaki, A Papadopoulou, E Athanasiou… - Arthritis & …, 2010 - Wiley Online Library
Objective To explore the effect of bortezomib in splenocytes and fibroblast‐like synoviocytes
(FLS) and its in vivo potency in a rat model of adjuvant‐induced arthritis (AIA), which …