Poly (ADP-ribose)-1 (PARP-1) is a key mediator of cell death in excitotoxicity, ischemia, and
oxidative stress. PARP-1 activation leads to cytosolic NAD+ depletion and mitochondrial …

Apoptosis and the rapid clearance of apoptotic cells (ACs) by professional or
nonprofessional phagocytes are normal and coordinated processes that ensure controlled …

The race for a cure to cancer continues, fueled by unprecedented discoveries of
fundamental biology underlying carcinogenesis and tumorigenesis. The expansion of the …

Hydrogen peroxide (H2O2), a biologically relevant, non-radical oxidizing species, may be
formed in tissues through oxidative processes, but there has been limited information …

Adiponectin is an important antiatherogenic adipocytokine that inhibits inflammation, insulin
resistance, and oxide stress. Inflammation in the vascular adventitia is a crucial factor in the …

Background In this study, we tested the ability of a novel poly (adenosine diphosphate
ribose) polymerase (PARP) inhibitor, 10‐(4‐methyl‐piperazin‐1‐ylmethyl)‐2H‐7‐oxa‐1, 2 …

There is an increase in reactive oxygen and nitrogen species in cardiomyocytes during
myocardial ischemia/reperfusion injury. This leads to oxidative DNA damage and activation …

US7759315B2 - Treatment of inflammatory conditions of the intestine - Google Patents
US7759315B2 - Treatment of inflammatory conditions of the intestine - Google Patents …

An excessive expression of poly (ADP‐ribose) polymerase (PARP) has been demonstrated
to play a key role in the pathogenesis of Parkinson's disease (PD). Here we investigated the …

PD98059 (MEK1 Inhibitor) has been shown to act in vivo as a highly selective inhibitor of
MEK1 activation and the MAP kinase cascade. In the present study, we have investigated …