There is considerable evidence for induction of differential risk of noncommunicable
diseases in humans by variation in the quality of the early life environment. Studies in animal …

An organism's behavioral and physiological and social milieu influence and are influenced
by the epigenome, which is composed predominantly of chromatin and the covalent …

Context Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology
of suicidal behavior andBDNFlevels are decreased in the brain and plasma of suicide …

Background Prenatal and early postnatal exposure to maternal depression may “program”
childhood behavior via epigenetic processes such as DNA methylation …

The critical role of social interactions in driving phenotypic variation has long been inferred
from the association between early social deprivation and adverse neurodevelopmental …

The epigenome is the overall epigenetic state of a cell and represents the ensemble of
chromatin modifications. It is an essential mechanism for the regulation of the genome that …

Longitudinal studies in humans demonstrate the association between prenatal and
postnatal experiences of adversity and long-term changes in neurodevelopment. These …

The true understanding of what we currently define as epigenetics evolved over time as our
knowledge on DNA methylation and chromatin modifications and their effects on gene …

Aberrant biochemical processes in the brain frequently go along with subtle shifts of the
cellular epigenetic profile that might support the pathogenic progression of psychiatric …

A number of recent studies have shown epigenetic alterations associated with suicidal
behavior. These epigenetic mechanisms, which alter gene expression via alternative …