Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …

In pharmaceutical research, an adequate cell-based assay scheme to efficiently screen and
to validate potential drug candidates in the initial stage of drug discovery is crucial. In order …

Within the global pharmaceutical and biotech industries, there is significant interest in
identifying in vitro screening systems that are more human-relevant—ie, that offer greater …

Hepatitis C virus (HCV) remains a major public health problem, affecting approximately 130
million people worldwide. HCV infection can lead to cirrhosis, hepatocellular carcinoma, and …

Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver
failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a …

Despite extensive research into the biomedical and pharmaceutical applications of
nanoparticles, and the liver being the main detoxifying organ in the human body, there are …

We describe a perfusion-based microfluidic device for three-dimensional (3D) dynamic
primary human hepatocyte cell culture. The microfluidic device was used to promote and …

In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with
HepG2 liver cells for applications in high throughput drug screening. We have studied the …

Tissue engineering for in vitro drug-screening applications based on tissue function is an
active area of translational research. Compared to targeted high-throughput drug-screening …

Background To date, biological components have been incorporated into MEMS devices to
create cell-based sensors and assays, motors and actuators, and pumps. Bio-MEMS …