Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …

Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases, resulting in hypoxia in the cancer …

Levels of melatonin in mammalian circulation are well documented; however, its levels in
tissues and other body fluids are yet only poorly established. It is obvious that melatonin …

This study investigated the effect of aging‐related parameters such as inflammation,
oxidative stress and cell death in the heart in an animal model of accelerated senescence …

This survey summarizes the limited findings related to the ability of endogenously produced
and exogenously administered melatonin to modify the response of the heart musculature to …

Spinal cord injury (SCI) is damage to the spinal cord caused by the trauma or disease that
results in compromised or loss of body function. Subsequent to SCI in humans, many …

The mechanisms responsible for the antihypertensive effect of melatonin are not completely
understood. To elucidate the possible role of the nitric oxide (NO) pathway in the …

Left ventricular hypertrophy (LVH), despite its adaptive nature, increases cardiovascular
morbidity and mortality. Novel approaches for protection against pathological heart …

Melatonin and its precursor, l‐tryptophan, have been shown to exert gastroprotective effects
in animals, but their influence on the gastric damage by aspirin (ASA) in humans has been …