The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Platelet factor-4 (PF4), a platelet-derived chemokine, has two important functions in the
vasculature. It has a pro-atherogenic role while also having anti-angiogenic effects. The …

Abstract p66Shc, a 66 kDa proto-oncogene Src homologous-collagen homologue (Shc)
adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and …

Gliomas generally infiltrate the surrounding normal brain parenchyma, a process associated
with increased vascular permeability (VP) and dysregulation of the blood–brain barrier …

The bidirectional communication between integrin αvβ3 and vascular endothelial growth
factor (VEGF) receptors acts to integrate and coordinate endothelial cell (EC) activity during …

Members of Shc (src homology and collagen homology) family, p46shc, p52shc, p66shc
have known to be related to cell proliferation and carcinogenesis. Whereas p46shc and …

Nrf2 transcription factor plays a crucial role in protection of cells against oxidative stress.
Under normal conditions Nrf2 is sequestered in cytoplasm by a cytoskeletal protein, Keapl …

Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional
chemotherapy. The presence of both cellular and stromal fibronectin (FN) and its interaction …

Adaptor protein Shc plays a key role in mitogen-activated protein kinase (MAPK) signaling
pathway, which can be mediated through a number of different receptors including integrins …

To assess the importance of carbohydrate moieties to the anti‐angiogenic activity of
plasminogen fragments, we cloned the fragment corresponding to amino acids Val79 to …