Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

Pulmonary embolism should be suspected in all patients who present with new or
worsening dyspnea, chest pain, or sustained hypotension without a clear alternative cause …

Background: Case-fatality rates are important for assessing the risks and benefits of
anticoagulation in patients with venous thromboembolism (VTE). Purpose: To summarize …

Venous thrombosis is a common disease that frequently recurs. Recurrence can be
prevented by anticoagulants, albeit at the cost of bleeding. Thus, assessment of the risk of …

2146 female Nurses' Health Study, obesity tripled the risk of unprovoked PE. 7 Hypertension
predisposes to both atherothrombosis and VTE. Hypertension is associated with a 50 …

Arterial thrombosis and venous thrombosis are common problems facing clinicians. Some
patients with thrombosis have an underlying hypercoagulable state. These states can be …

Warfarin demonstrates a wide interindividual variability in response that is mediated partly
by variants in cytochrome P450 2C9 (CYP2C9) and vitamin K 2, 3‐epoxide reductase …

Background: Whether patients with unprovoked venous thromboembolism (VTE) have a
higher risk of arterial cardiovascular events than the general population and patients with …

Summary Background: CYP2C9 and VKORC1 genotypes predict therapeutic warfarin dose
at initiation of therapy; however, the predictive ability of genetic information after a week or …

Most large or fatal pulmonary embolisms (PE) at autopsy were unsuspected ante mortem.
Newly identified clinical characteristics of PE enhance our ability to identify potential …