Central nervous system (CNS) development, homeostasis, stress responses, and plasticity
are all mediated by epigenetic mechanisms that modulate gene expression and promote …

Genomic tiling arrays, cDNA sequencing and, more recently, RNA-Seq have provided initial
insights into the extent and depth of transcribed sequence across human and other …

Adherens junctions (AJs), which are organized by adhesion proteins and the underlying
actin cytoskeleton, probably sense pulling forces from adjacent cells and modulate opposing …

A series of reports over the last few years have indicated that a much larger portion of the
mammalian genome is transcribed than can be accounted for by currently annotated genes …

Experimental evidence suggests that half or more of the mammalian transcriptome consists
of noncoding RNA. Noncoding RNAs are divided into short noncoding RNAs (including …

Long non-coding RNAs (lncRNAs) are mRNA-like, non-protein-coding RNAs that are
pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating …

Background Discovery that the transcriptional output of the human genome is far more
complex than predicted by the current set of protein-coding annotations and that most RNAs …

The current view of gene regulation in complex organisms holds that gene expression is
largely controlled by the combinatoric actions of transcription factors and other regulatory …

Background Long considered to be the building block of life, it is now apparent that protein is
only one of many functional products generated by the eukaryotic genome. Indeed, more of …

The central dogma of molecular biology relegates RNAs to the role of “messengers” of
genetic information, with proteins as the end products that perform key roles as regulators …