Mammalian airways are protected from infection by a thin film of airway surface liquid (ASL)
which covers airway epithelial surfaces and acts as a lubricant to keep mucus from adhering …

Background The PLUNC (“Palate, lung, nasal epithelium clone”) protein is an abundant
secretory product of epithelia present throughout the conducting airways of humans and …

The metabolic sensor AMP-activated kinase (AMPK) inhibits both the cystic fibrosis (CF)
transmembrane conductance regulator (CFTR) Cl− channel and epithelial Na+ channel …

Effective clearance of inhaled pathogens is the primary innate defense mechanism in the
lung, and requires the maintenance of a proper airway surface liquid (ASL) volume to …

Background The airway mucus in patients with cystic fibrosis (CF) is dehydrated and
adhesive and accumulates in the airways, resulting in chronic inflammation, infection, and …

Mucociliary clearance increases with increasing doses of mannitol and clearance is
enhanced when mannitol inhalation is followed by repetitive voluntary coughing. The aim of …

Asthmatics with overproduction of mucus that is viscous and sticky have impaired
mucociliary clearance (MCC) leading to mucus plugs, and airway obstruction. Inhaled …

Furosemide, a potent diuretic, affects ion and water movement across the respiratory
epithelium. However, the effects of furosemide, as clinically used, on mucociliary clearance …

A clinical program to assess whether lipid GL67A–mediated gene transfer can ameliorate
cystic fibrosis (CF) lung disease is currently being undertaken by the UK CF Gene Therapy …

The article provides information on cystic fibrosis (CF) including survival trends, disease
variability and future treatment choices. CF refers to a genetic disorder that has a …