Alzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly.
Thus far, there is no curative treatment for this devastating condition, thereby creating …

The present mini-review highlights the recent developments on different classes of synthetic
hybrids of natural and/or unnatural bioactive compounds, the utilization of which is very …

Plants have been found to be useful as memory enhansers as well as antiaging. Twenty two
of such plants from sixteen families were investigated for their acetylcholinesterase (AChE) …

Isosorbide-2-benzyl carbamate-5-benzoate is a highly potent and selective BuChE inhibitor.
Meanwhile, isosorbide-2-aspirinate-5-salicylate is a highly effective aspirin prodrug that …

A significant acetylcholinesterase (AChE) inhibitory activity was observed for the hexane
extract from the bark of Mesua elegans (Clusiaceae). Thus, the hexane extract was …

Dimebon, originally developed as an anti-histamine drug, is being re-purposed for new
indications as an effective treatment for patients suffering from Alzheimer's and Huntington's …

Dual binding site acetylcholinesterase inhibitors have recently emerged as a new class of
anti-Alzheimer agents with potential to positively modify the course of the disease. These …

Importance of the field: Cholinesterase inhibitors are the mainstay of symptomatic therapy for
Alzheimer's disease (AD). Rivastigmine, an inhibitor of both acetylcholinesterase and …

Cholinesterase inhibitors constitute one of the mainstays of treatment of Alzheimer disease
(AD). Gastrointestinal side effects, difficulty accessing therapeutic doses and poor patient …

以对羟基苯甲醛或间羟基苯甲醛为原料, 用(R) 或(S)-叔丁基亚磺酰胺为手性引发剂,
设计合成了(S)-卡巴拉汀及其12 个未见文献报道的类似物, 其结构通过IR, 1 H NMR, 13 C NMR …