Phosphorylation of the RNA polymerase (Pol) II C-terminal domain (CTD) repeats (1-
YSPTSPS-7) is coupled to transcription and may act as a'code'that controls mRNA synthesis …

Phosphorylation of the C-terminal domain (CTD) of RNA polymerase II controls the co-
transcriptional assembly of RNA processing and transcription factors. Recruitment relies on …

Eukaryotic RNA polymerase II produces an astounding diversity of transcripts. These may
need to be 5′ capped, spliced, polyadenylated, and packaged with proteins before their …

With a simple tandem iterated sequence, the carboxyl terminal domain (CTD) of eukaryotic
RNA polymerase II (RNAP II) serves as the central coordinator of mRNA synthesis by …

Over the last few years, the development of large-scale technologies has radically modified
our conception of genome-wide transcriptional control by unveiling an unexpected high …

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of malignant,
apoptosis‐resistant B CD19+/CD5+ cells. Populations of CLL cells are heterogeneous and …

Heterochromatic silencing is important for repressing gene expression, protecting cells
against viral invasion, maintaining DNA integrity and for proper chromosome segregation …

In eukaryotic cells, the transcription of genes is accurately orchestrated both spatially and
temporally by the C-terminal domain of RNA polymerase II (CTD). The CTD provides a …

Nuclear polyadenylated RNA-binding (Nab) 3 protein is an RNA-binding protein that is
involved in the poly (A) independent termination pathway. Here, we report the NMR spectral …

Abstract RNA Polymerase II (Pol II) is the central enzyme in eukaryotic mRNA transcription.
In recent years, structural studies have provided insights into the mechanism of Pol II. A full …