Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

The discovery of the HD (Huntington's disease) gene in 1993 led to the creation of genetic
mouse models of the disease and opened the doors for mechanistic studies. In particular …

Caspase cleavage of huntingtin (htt) and nuclear htt accumulation represent early
neuropathological changes in brains of patients with Huntington's disease (HD). However …

Excitotoxicity plays a key role in the selective vulnerability of striatal neurons in Huntington
disease (HD). Decreased glutamate uptake by glial cells could account for the excess …

Since the identification of the gene responsible for HD (Huntington's disease), many genetic
mouse models have been generated. Each employs a unique approach for delivery of the …

Huntington's disease (HD) is neither a fatal hereditary neurodegenerative disorder without
satisfactory treatments nor a cure. It is caused by a CAG repeat expansion in the huntingtin …

Highlighting advances in the discovery and development of new drug therapies for
neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many …

Experimentally induced lesions of basal ganglia cause neurological anomalies such as
hindlimb clasping and changes in motor activity, together with deficits in motor coordination …

Since the identification of the gene responsible for HD (Huntington's disease), many genetic
mouse models have been generated. Each employs a unique approach for delivery of the …

Huntington Disease (HD) is a neurodegenerative disorder caused by expansion of a poly-
glutamine tract in the huntingtin (htt) protein. Poly-glutamine (polyQ) expansion of huntingtin …