Objectives: The purpose of this study was to summarize the evidence of pre-procedural
statin therapy to reduce periprocedure cardiovascular events. Background: Invasive …

The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the
treatment of hyperlipidemia, and in the long-term prevention of coronary artery disease and …

Objectives: This study sought to determine the efficacy of high-dose atorvastatin in patients
with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous …

OBJECTIVE: To test the hypothesis that perioperative statin use reduces acute kidney injury
(AKI) after cardiac surgery. DESIGN: A retrospective analysis of prospectively collected data …

Periprocedural myocardial injury (PMI) is common after percutaneous coronary intervention
(PCI). Periprocedural infarction (myocardial infarction type 4a) occurs after at least 10% of …

Background—Vascular inflammation can lead to plaque instability and acute coronary
syndromes (ACS). Viruses produce potent immunomodulating proteins that regulate key …

Vascular cell apoptosis, an active form of programmed cell death, plays an integral role in
atherosclerosis and in-stent restenosis after angioplasty, thus promoting the precipitation of …

Evidence is mounting that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
(statins) have a number of pleiotropic effects over and above their lipid-lowering properties …

Background Extensively used lipid-lowering statins have also non-lipid-lowering, pleiotropic
effects. Previous studies have demonstrated that a pre-procedural single dose of …

Objective—To evaluate whether a p38α/β mitogen-activated protein kinase inhibitor, SB-
681323, would limit the elevation of an inflammatory marker, high-sensitivity C-reactive …