Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

Congenital long QT syndrome (LQTS) is a hereditary disorder that leads to sudden cardiac
death secondary to fatal cardiac arrhythmias. Although many genes for LQTS have been …

J. Neurochem.(2010) 114, 1424–1435. Abstract Oxytocin receptor is a seven
transmembrane receptor widely expressed in the CNS that triggers Gi or Gq protein …

Tamoxifen inhibits transmembrane currents of the Kir2. x inward rectifier potassium channels
by interfering with the interaction of the channels with membrane phosphatidylinositol 4, 5 …

Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epilepsies
(IGEs), affecting 12–30% of all epilepsies in medical centers. To date genetic linkage studies …

K+ channels in the heart shape the cardiac action potential, and many existing drugs can
inhibit or activate these currents. In particular, their potential therapeutic benefit has been …

For me, it takes only a short bout of insomnia to trigger an acute awareness and reflection on
the pacemaker mechanisms of the heart. In my quiet wakefulness, attempting to suppress …

The invention relates to processes for identifying inhibitors and activators of eukaryotic
potassium channels, in which a mutated S. cerevisiae cell is used whose endogenous …

Cyclic nucleotide-gated ion channels (CNGs) are non-selective cation channels, which are
opened by the direct binding of cyclic nucleotides (cAMP and cGMP). CNG channels were …

Heterotrimeric GTP-binding proteins (G proteins) transduce the signals of heptahelical
membrane proteins, so called G proteincoupled receptors (GPCR), to a number of effectors …