The notch signaling pathway is evolutionarily conserved across the animal kingdom and
regulates developmental 'decisions', such as cell fate commitment, differentiation …

Germinal centers (GCs) are specialized microenvironments in secondary lymphoid organs
that facilitate the development of high-affinity, isotype-switched Abs, and immunological …

The B cell-activating factor of the TNF family receptor (BAFF-R), encoded by the
TNFRSF13C gene, is critically important for transitional B cell survival to maturity. Thus …

We previously showed that agonistic antibodies to CD40 could substitute for CD4 T-cell help
and prevent reactivation of murine gammaherpesvirus 68 (MHV-68) in the lungs of major …

B-cell antigen receptor (BCR)[engagement by antigen/signalling] contributes to Chronic
lymphocytic leukaemia (CLL)-cell selection and survival. This signalling pathway has been …

BAFF, a TNF-like ligand, has emerged as an essential factor for B-cell survival and
maturation, and the discovery of this factor has been a major advance for understanding B …

The biochemical pathways critical to B cell development remain poorly defined. Here I
characterize a critical role for two separate families of proteins, Akt and Presenilin in the …

Humoral immunity is characterized by an early primary response of short lived plasma cells
(SLPCs) secreting low affinity antibody followed by the formation of germinal center (GC) …

During a T cell-dependent B cell immune response, cognate interactions with helper T cells
result in B cells differentiating into short-lived antibody-forming cells (AFCs) or initiating …

Identifizierung und Phänotypisierung autoantigenspezifischer Plasmazellen bei Patienten mit
Bullösem Pemphigoid Susanne Lászl Page 1 Aus der Klinik und Poliklinik für Dermatologie und …