Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution

D Bolliger, K Görlinger, KA Tanaka… - The Journal of the …, 2010 - pubs.asahq.org
Fluid resuscitation after massive hemorrhage in major surgery and trauma may result in
extensive hemodilution and coagulopathy, which is of a multifactorial nature. Although …

[HTML][HTML] APC resistance: biological basis and acquired influences

E Castoldi, J Rosing - Journal of thrombosis and haemostasis, 2010 - Elsevier
Proteolytic inactivation of factors Va (FVa) and VIIIa (FVIIIa) by activated protein C (APC) and
its cofactors protein S and factor V (FV) is a key process in the physiological down …

[HTML][HTML] Bisarylhydrazones as Exchangeable Biocompatible Linkers

A Dirksen, S Yegneswaran… - … Chemie (International ed …, 2010 - ncbi.nlm.nih.gov
The selective enrichment of tagged molecules from complex biological mixtures is of primary
importance for methods in chemical biology and proteomics. Affinity purification on (strept) …

[HTML][HTML] Etiology and long-term outcome of extrahepatic portal vein obstruction in children

B Weiss, E Shteyer, A Vivante, D Berkowitz… - World journal of …, 2010 - ncbi.nlm.nih.gov
AIM: To study the management and outcome of children with extrahepatic portal vein
obstruction (EHPVO) in a whole country population. METHODS: A nationwide multicenter …

The Kunitz-3 domain of TFPI-α is required for protein S–dependent enhancement of factor Xa inhibition

M Ndonwi, EA Tuley, GJ Broze Jr - Blood, The Journal of the …, 2010 - ashpublications.org
Protein S (PS) enhances the inhibition of factor Xa (FXa) by tissue factor pathway inhibitor-α
(TFPI-α) in the presence of Ca2+ and phospholipids. Altered forms of recombinant TFPI-α …

[HTML][HTML] Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma

E Castoldi, P Simioni, D Tormene, J Rosing… - Journal of thrombosis …, 2010 - Elsevier
Background: Protein S and tissue factor pathway inhibitor (TFPI) act together in down‐
regulating coagulation. Objective: To investigate the TFPI/protein S system in hereditary and …

C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S–independent mechanism: results from genome-wide association and …

A Buil, DA Trégouët, JC Souto, N Saut… - Blood, The Journal …, 2010 - ashpublications.org
Through its binding with protein S (PS), a key element of the coagulation/fibrinolysis
cascade, the C4b-binding protein (C4BP) has been hypothesized to be involved in the …

Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game

Z Bereczky, KB Kovács, L Muszbek - 2010 - degruyter.com
Protein C (PC) and protein S (PS) are vitamin K-dependent glycoproteins that play an
important role in the regulation of blood coagulation as natural anticoagulants. PC is …

[HTML][HTML] Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency

E Castoldi, LFA Maurissen, D Tormene, L Spiezia… - …, 2010 - ncbi.nlm.nih.gov
Background Protein S, which circulates in plasma in both free and bound forms, is an
anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor …

[HTML][HTML] Thrombin generation‐based assays to measure the activity of the TFPI–protein S pathway in plasma from normal and protein S‐deficient individuals

LFA Maurissen, E Castoldi, P Simioni, J Rosing… - Journal of Thrombosis …, 2010 - Elsevier
Background: Protein S acts as a cofactor for full‐length tissue factor pathway inhibitor (TFPI)
in the downregulation of thrombin formation. Objective: To develop a functional test to …